Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis
نویسندگان
چکیده
منابع مشابه
Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis.
Astrocyte-elevated gene-1 (AEG-1) expression is increased in multiple cancers and plays a central role in Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Additionally, overexpression of AEG-1 protects primary and transformed human and rat cells from serum starvation-induced apoptosis through activation of PI3K/Akt signaling. These findings sug...
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Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by diverse etiology, activation of multiple signal transduction pathways, and various gene mutations. Here, we have determined a specific role for astrocyte elevated gene-1 (AEG1) in HCC pathogenesis. Expression of AEG1 was extremely low in human hepatocytes, but its levels were significantly increased in human ...
متن کاملOverexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis.
Astrocyte elevated gene-1 (AEG-1), upregulated in various types of human cancers, has been reported to be associated with the carcinogenesis of human cancer. However, the functional significance of AEG-1 in human esophageal squamous cell carcinoma (ESCC) remains unknown. In the present study, we showed the expression of AEG-1 was markedly upregulated in esophageal cancer cell lines and surgical...
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Astrocyte-elevated gene-1 (AEG-1) expression increases in multiple cancers and plays a crucial role in oncogenic transformation and angiogenesis, which are essential components in tumor cell development, growth, and progression to metastasis. Moreover, AEG-1 directly contributes to resistance to chemotherapeutic drugs, another important hallmark of aggressive cancers. In the present study, we d...
متن کاملبهینه سازی محصول PCRتوالی پروموترغنی ازG+C ژن انسانی Astrocyte elevated gene -1
چکیده زمینه و هدف: اکثر ژن‌های خانه‌دار، سرکوبگر تومور، و تقریبا 40% ژن‌های اختصاصی بافت‌ها حاوی توالی غنی از G+C در نواحی پروموتری خود می‌باشند که تکثیر آن با مشکلات زیادی همراه است. ژنAstrocyte elevated gene -1(AEG-1) دارای نقش عملکردی در چندین مرحله از پیشرفت تومور از جمله، ترانسفورماسیون، آپوپتوزیس، متاستاز، مقاومت به شیمی درمانی، رگزایی و پیری سلول می‌باشد. مواد و روش کار: این مطالعه، به ب...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.661801